Right now, doctors at select centers in the U.S. are accepting participants for a new phase 2 clinical trial.
The study is for AMX0035, an oral combination of two small molecules, sodium phenylbutyrate (PB) and tauroursodeoxycholic acid (TUDCA). Each compound has shown efficacy in several cellular and animal models of ALS.
Small clinical trials have supported both the potential of slowing decline due to ALS and safety of these compounds, however this larger trial is needed to confirm these findings.
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ALS is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Eventually, people with ALS lose the ability to initiate and control muscle movement, which leads to total paralysis and death, usually within two to five years of diagnosis.
Dr. Sabrina Paganoni from Massachusetts General Hospital discusses CENTAUR, a phase 2 trial for people with ALS.
The staff at your clinical trial site will help determine if you meet the criteria for the study. This study is looking for individuals who are:
Participating in the study will last for approximately 30-34 weeks, and includes:
The CENTAUR-OLE study provides patients with the option of continuing treatment once they have completed the 24-week study period.
The trial will evaluate AMX0035’s ability to have an impact on daily functioning, muscle strength, and respiratory function as well as its ability to alter biological markers of ALS.
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