Has your loved one been diagnosed with ALS?
Clara Health
Partner

Has your loved one been diagnosed with ALS?

Learn about a new, no-cost investigational therapy that could help them manage their symptoms.


Right now, doctors at select centers in the U.S. are accepting participants for a new clinical research study to evaluate how AMX0035 may be able to help slow decline due to ALS.

AMX0035 is an oral combination of two small molecules, sodium phenylbutyrate (PB) and tauroursodeoxycholic acid (TUDCA). Each compound has shown efficacy in several cellular and animal models of ALS.

Small clinical trials have supported the potential for safety and efficacy of these compounds; however, this larger trial is needed to confirm these findings.

To learn more, please fill out the application below.

About 
ALS

ALS is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Eventually, people with ALS lose the ability to initiate and control muscle movement, which leads to total paralysis and death, usually within two to five years of diagnosis.

About this study

Dr. Sabrina Paganoni from Massachusetts General Hospital discusses CENTAUR,
a phase 2 trial for people with ALS.

Is the CENTAUR study right for my loved one?

Who is this study for?

The staff at the nearest clinical trial site will help determine if your loved one meets the criteria for the study. This study is looking for individuals who are:

  • Male or female, aged 18-80 years of age
  • Have had less than or equal to 18 months since their ALS symptom onset
  • Additional criteria to be evaluated

 

What should I expect?

Participating in the study will last for approximately 30-34 weeks, and includes:

  • 24 weeks of treatment
  • Additional screening assessments, which will take up to 6 weeks
  • 4 weeks of safety follow up after the treatment is completed

 

Frequently asked questions

Will the treatment be available after the study ends?

The CENTAUR-OLE study provides patients with the option of continuing treatment once they have completed the 24-week study period.

What will this study evaluate?

The trial will evaluate AMX0035’s ability to have an impact on daily functioning, muscle strength, and respiratory function as well as its ability to alter biological markers of ALS.

Additional details

"To accelerate developing new treatments for ALS, the two foundations issued a global, competitive call for grant proposals for therapies that had a strong scientific rationale and where a biomarker of drug effect could be measured. AMX0035 was chosen as one of the top new therapeutic candidates to bring forward for ALS."

- Merit Cudkowicz, MD, Chief Medical Officer for ALS Finding A Cure and Chief of Neurology at Massachusetts General HospitalMerit Cudkowicz

Have a question?

For more information, fill out the form, contact (617-724-7210), or email Emily Engel at eengel@partners.org